Wetenschappelijk onderzoek

Naast de zorg voor patiënten verrichten we wetenschappelijk onderzoek op het gebied van diagnose en behandeling van primaire en verworven immuundeficiënties en immuundysregulatie.

Selectie publicaties 2024

volgt

Selectie publicaties 2023

Lack of eosinophil extracellular trap formation due to failure of plasma membrane breakdown in the absence of elastase

Sprenkeler EGG, Goetschalckx I, Fernández Hermira S, Tool ATJ, Hoogenboezem M, van Bruggen R, Kuijpers TW. 

Blood Adv. 2023 Jul 10:bloodadvances.2022009432. doi: 10.1182/bloodadvances.2022009432.

B-cell targeting with anti-CD38 daratumumab: implications for differentiation and memory responses

Verhoeven D, Grinwis L, Marsman C, Jansen MH; T2B Consortium; Van Leeuwen EM, Kuijpers TW. 

Life Sci Alliance. 2023 Jul 7;6(9):e202302214. doi: 10.26508/lsa.202302214.

Clinical Symptoms, Laboratory Parameters and Long-Term Follow-up in a National DADA2 Cohort

Andriessen MVE, Legger GE, Bredius RGM, van Gijn ME, Hak AE, Muller PCEH, Kamphuis S, Klouwer FCC, Kuijpers TW, Leavis HL, Nierkens S, Rutgers A, van der Veken LT, van Well GTJ, Mulders-Manders CM, van Montfrans JM. 

J Clin Immunol. 2023 Jun 5. doi: 10.1007/s10875-023-01521-8.

Efficient complement-mediated clearance of immunosuppressed T cells by macrophages

Gankema AAF, Furumaya C, Fernández-Hermira S, Hoogenboezem M, Matlung HL, van Bruggen R, Kuijpers TW. 

Front Immunol. 2023 May 16;14:1183180. doi: 10.3389/fimmu.2023.1183180.

Primary SARS-CoV-2 infection in patients with immune-mediated inflammatory diseases: long-term humoral immune responses and effects on disease activity

van Dam KPJ, Volkers AG, Wieske L, Stalman EW, Kummer LYL, van Kempen ZLE, Killestein J, Tas SW, Boekel L, Wolbink GJ, van der Kooi AJ, Raaphorst J, Takkenberg RB, D'Haens GRAM, Spuls PI, Bekkenk MW, Musters AH, Post NF, Bosma AL, Hilhorst ML, Vegting Y, Bemelman FJ, Voskuyl AE, Broens B, Sanchez AP, van Els CACM, de Wit J, Rutgers A, de Leeuw K, Horváth B, Verschuuren JJGM, Ruiter AM, van Ouwerkerk L, van der Woude D, Allaart RCF, Teng YKO, van Paassen P, Busch MH, Jallah PBP, Brusse E, van Doorn PA, Baars AE, Hijnen DJ, Schreurs CRG, van der Pol WL, Goedee HS, Steenhuis M, Keijzer S, Keijser JBD, Cristianawati O, Ten Brinke A, Verstegen NJM, van Ham SM, Rispens T, Kuijpers TW, Löwenberg M, Eftimov F; T2B! Immunity against SARS-CoV-2 study group.

BMC Infect Dis. 2023 May 17;23(1):332. doi: 10.1186/s12879-023-08298-6.

Humanized MISTRG as a preclinical in vivo model to study human neutrophil-mediated immune processes

Martinez-Sanz P, Laurent ARG, Slot E, Hoogenboezem M, Bąbała N, van Bruggen R, Rongvaux A, Flavell RA, Tytgat GAM, Franke K, Matlung HL, Kuijpers TW, Amsen D, Karrich JJ. 

Front Immunol. 2023 Mar 8;14:1105103. doi: 10.3389/fimmu.2023.1105103.

Distinct dynamics of antigen-specific induction and differentiation of different CD11c+Tbet+ B-cell subsets 

Steuten J, Bos AV, Kuijper LH, Claireaux M, Olijhoek W, Elias G, Duurland MC, Jorritsma T, Marsman C, Paul AGA, Garcia Vallejo JJ, van Gils MJ, Wieske L, Kuijpers TW, Eftimov F, van Ham SM, Ten Brinke A; T2B Consortium. 

J Allergy Clin Immunol. 2023 Feb 27:S0091-6749(23)00234-8. doi: 10.1016/j.jaci.2023.02.020.

Persistence of seroconversion at 6 months following primary immunisation in patients with immune-mediated inflammatory diseases

Wieske L, Stalman EW, van Dam PJK, Kummer LY, Steenhuis M, van Kempen ZLE, Killestein J, Volkers AG, Tas SW, Boekel L, Wolbink G, Van der Kooi A, Raaphorst J, Löwenberg M, Takkenberg B, D'Haens GRAM, Spuls PI, Bekkenk MW, Musters AH, Post NF, Bosma AL, Hilhorst ML, Vegting Y, Bemelman FJ, Voskuyl A, Broens B, Parra Sanchez A, van Els CACM, Wit J, Rutgers A, de Leeuw K, Horváth B, Verschuuren JJGM, Ruiter AM, van Ouwerkerk L, van der Woude D, Allaart CF, Teng YKO, van Paassen P, Busch MH, Jallah PBP, Brusse E, van Doorn PA, Baars AE, Hijnen D, Schreurs CRG, Van der Pol WL, Goedee HS, Keijzer S, Keijser J, Cristianawati O, Ten Brinke A, Verstegen NJM, Zwinderman KAH, van Ham SM, Kuijpers TW, Rispens T, Eftimov F; T2B! immunity against SARS-CoV-2 study group.

 Ann Rheum Dis. 2023 Jun;82(6):883-885. doi: 10.1136/ard-2022-223464.

Hematologically important mutations: Leukocyte adhesion deficiency (second update)

Roos D, van Leeuwen K, Madkaikar M, Kambli PM, Gupta M, Mathews V, Rawat A, Kuhns DB, Holland SM, de Boer M, Kanegane H, Parvaneh N, Lorenz M, Schwarz K, Klein C, Sherkat R, Jafari M, Wolach B, den Dunnen JT, Kuijpers TW, Köker MY. 

Blood Cells Mol Dis. 2023 Mar;99:102726. doi: 10.1016/j.bcmd.2023.102726.

Febrile illness in high-risk children: a prospective, international observational study

van der Velden FJS, de Vries G, Martin A, Lim E, von Both U, Kolberg L, Carrol ED, Khanijau A, Herberg JA, De T, Galassini R, Kuijpers TW, Martinón-Torres F, Rivero-Calle I, Vermont CL, Hagedoorn NN, Pokorn M, Pollard AJ, Schlapbach LJ, Tsolia M, Elefhteriou I, Yeung S, Zavadska D, Fink C, Voice M, Zenz W, Kohlmaier B, Agyeman PKA, Usuf E, Secka F, de Groot R, Levin M, van der Flier M, Emonts M; PERFORM consortium. 

Eur J Pediatr. 2023 Feb;182(2):555-556. doi: 10.1007/s00431-022-04788-y. Erratum for: Eur J Pediatr. 2023 Feb;182(2):543-554.

A Novel Deletion in FERMT3 Causes LAD-III in a Turkish Family

Köker N, Deveci İ, van Leeuwen K, Akbayram S, Roos D, Kuijpers TW, Köker MY. 

J Clin Immunol. 2023 May;43(4):741-746. doi: 10.1007/s10875-022-01420-4.

Neutrophil interactions with T cells, platelets, endothelial cells, and of course tumor cells

Segal BH, Giridharan T, Suzuki S, Khan ANH, Zsiros E, Emmons TR, Yaffe MB, Gankema AAF, Hoogeboom M, Goetschalckx I, Matlung HL, Kuijpers TW. 

Immunol Rev. 2023 Mar;314(1):13-35. doi: 10.1111/imr.13178

Health Outcomes and Cost-effectiveness of Monoclonal SARS-CoV-2 Antibodies as Pre-exposure Prophylaxis

Popping S, Nichols BE, Appelman B, Biemond JJ, Vergouwe M, Rosendaal FR, van der Valk M, de Bree GJ, Wiersinga WJ, Birnie E; TURN-COVID study group. 

JAMA Netw Open. 2023 Jul 3;6(7):e2321985. doi: 10.1001/jamanetworkopen.2023.21985.

Crosstalk between TLR8 and RIG-I-like receptors enhances antiviral immune responses

Vlaming KE, van Wijnbergen K, Kaptein TM, Nijhuis M, Kootstra NJ, de Bree GJ, Geijtenbeek TB. 

Front Med (Lausanne). 2023 May 16;10:1146457. doi: 10.3389/fmed.2023.1146457

Immune Responses 6 Months After mRNA-1273 COVID-19 Vaccination and the Effect of a Third Vaccination in Patients with Inborn Errors of Immunit

van Leeuwen LPM, Grobben M, GeurtsvanKessel CH, Ellerbroek PM, de Bree GJ, Potjewijd J, Rutgers A, Jolink H, van de Veerdonk FL, van Gils MJ, de Vries RD, Dalm VASH; VACOPID Research Group.

J Clin Immunol. 2023 Aug;43(6):1104-1117. doi: 10.1007/s10875-023-01514-7.

Fourth mRNA COVID-19 vaccination in immunocompromised patients with haematological malignancies (COBRA KAI): a cohort study

Hofsink Q, Haggenburg S, Lissenberg-Witte BI, Broers AEC, van Doesum JA, van Binnendijk RS, den Hartog G, Bhoekhan MS, Haverkate NJE, van Meerloo J, Burger JA, Bouhuijs JH, Smits GP, Wouters D, van Leeuwen EMM, Bontkes HJ, Kootstra NA, Vogels-Nooijen S, Rots N, van Beek J, Heemskerk MHM, Groen K, van Meerten T, Mutsaers PGNJ, van Gils MJ, Goorhuis A, Rutten CE, Hazenberg MD, Nijhof IS; COBRA KAI study team.

EClinicalMedicine. 2023 Jul;61:102040. doi: 10.1016/j.eclinm.2023.102040.

Selectie publicaties 2022

Breakthrough infections with the SARS-CoV-2 omicron (B.1.1.529) variant in patients with immune-mediated inflammatory diseases

Stalman EW, Wieske L, van Dam KPJ, Kummer LY, van Kempen ZLE, Killestein J, Volkers AG, Tas SW, Boekel L, Wolbink GJ, Van der Kooi AJ, Raaphorst J, Löwenberg M, Takkenberg RB, D'Haens GRAM, Spuls PI, Bekkenk MW, Musters AH, Post NF, Bosma AL, Hilhorst ML, Vegting Y, Bemelman FJ, Voskuyl AE, Broens B, Parra Sanchez A, van Els CACM, Wit J, Rutgers A, de Leeuw K, Horváth B, Verschuuren JJGM, Ruiter AM, van Ouwerkerk L, van der Woude D, Allaart CF, Teng OYK, van Paassen P, Busch MH, Jallah PBP, Brusse E, van Doorn PA, Baars AE, Hijnen DJ, Schreurs CRG, Van der Pol WL, Goedee HS, Steenhuis M, Keijzer S, Keijser JBD, Boogaard A, Cristianawati O, Ten Brinke A, Verstegen NJM, Zwinderman KAH, Rispens T, van Ham SM, Kuijpers TW, Eftimov F; T2B! immunity against SARS-CoV-2 study group.

Ann Rheum Dis. 2022 Dec;81(12):1757-1766. doi: 10.1136/ard-2022-222904.

SARS-CoV-2 breakthrough infections in patients with immune-mediated inflammatory diseases during the omicron dominant period

Boekel L, Besten YR, Hooijberg F, Wartena R, Steenhuis M, Vogelzang E, Leeuw M, Atiqi S, Tas SW, Lems WF, van Ham SM, Eftimov F, Stalman EW, Wieske L, Kuijpers TW, Voskuyl AE, van Vollenhoven RF, Gerritsen M, Krieckaert C, Rispens T, Boers M, Nurmohamed MT, Wolbink G.

Lancet Rheumatol. 2022 Nov;4(11):e747-e750. doi: 10.1016/S2665-9913(22)00221-1.

Megalobastic anemia, infantile leukemia, and immunodeficiency caused by a novel homozygous mutation in the DHFR gene

Kuijpers TW, de Vries ACH, van Leeuwen EM, Ermens ATAM, de Pont S, Smith DEC, Wamelink MMC, Mensenkamp AR, Nelen MR, Lango Allen H, Pals ST, Beverloo BHB, Huidekoper HH, Wagner A.

Blood Adv. 2022 Nov 22;6(22):5829-5834. doi: 10.1182/bloodadvances.2022007233.

Immunodeficiency, autoimmunity, and increased risk of B cell malignancy in humans with TRAF3 mutations

Rae W, Sowerby JM, Verhoeven D, Youssef M, Kotagiri P, Savinykh N, Coomber EL, Boneparth A, Chan A, Gong C, Jansen MH, du Long R, Santilli G, Simeoni I, Stephens J, Wu K, Zinicola M, Allen HL, Baxendale H, Kumararatne D, Gkrania-Klotsas E, Scheffler Mendoza SC, Yamazaki-Nakashimada MA, Ruiz LB, Rojas-Maruri CM, Lugo Reyes SO, Lyons PA, Williams AP, Hodson DJ, Bishop GA, Thrasher AJ, Thomas DC, Murphy MP, Vyse TJ, Milner JD, Kuijpers TW, Smith KGC

Sci Immunol. 2022 Aug 12;7(74):eabn3800. doi: 10.1126/sciimmunol.abn3800.

Heterozygous NOTCH1 Variants Cause CNS Immune Activation and Microangiopathy

Helman G, Zarekiani P, Tromp SAM, Andrews A, Botto LD, Bonkowsky JL, Chassevent A, Giorgio E, Pippucci T, Wei S, Smith-Hicks C, Vaula G, Willemsen MAAP, Schimmel M, Vollert K, Shimizu F, Kanda T, Lynch M, Roscioli T, Taft RJ, Simons C, Bugiani M, Kuijpers TW, van der Knaap MS.

Ann Neurol. 2022 Nov;92(5):895-901. doi: 10.1002/ana.26477.

Population genomics of Group B Streptococcus reveals the genetics of neonatal disease onset and meningeal invasion

Chaguza C, Jamrozy D, Bijlsma MW, Kuijpers TW, van de Beek D, van der Ende A, Bentley SD.

Nat Commun. 2022 Jul 21;13(1):4215. doi: 10.1038/s41467-022-31858-4.

Optimized Protocols for In-Vitro T-Cell-Dependent and T-Cell-Independent Activation for B-Cell Differentiation Studies Using Limited Cells

Marsman C, Verhoeven D, Koers J, Rispens T, Ten Brinke A, van Ham SM, Kuijpers TW.

Front Immunol. 2022 Jun 29;13:815449. doi: 10.3389/fimmu.2022.815449.

Cancer cells resist antibody-mediated destruction by neutrophils through activation of the exocyst complex

van Rees DJ, Bouti P, Klein B, Verkuijlen PJH, van Houdt M, Schornagel K, Tool ATJ, Venet D, Sotiriou C, El-Abed S, Izquierdo M, Guillaume S, Saura C, Di Cosimo S, Huober J, Roylance R, Kim SB, Kuijpers TW, van Bruggen R, K van den Berg T, Matlung HL.

J Immunother Cancer. 2022 Jun;10(6):e004820. doi: 10.1136/jitc-2022-004820.

Breakthrough SARS-CoV-2 infections with the delta (B.1.617.2) variant in vaccinated patients with immune-mediated inflammatory diseases using immunosuppressants: a substudy of two prospective cohort studies

Boekel L, Stalman EW, Wieske L, Hooijberg F, van Dam KPJ, Besten YR, Kummer LYL, Steenhuis M, van Kempen ZLE, Killestein J, Volkers AG, Tas SW, van der Kooi AJ, Raaphorst J, Löwenberg M, Takkenberg RB, D'Haens GRAM, Spuls PI, Bekkenk MW, Musters AH, Post NF, Bosma AL, Hilhorst ML, Vegting Y, Bemelman FJ, Voskuyl AE, Broens B, Parra Sanchez A, van Els CACM, de Wit J, Rutgers A, de Leeuw K, Horváth B, Verschuuren JJGM, Ruiter AM, van Ouwerkerk L, van der Woude D, Allaart CF, Teng YKO, van Paassen P, Busch MH, Jallah PBP, Brusse E, van Doorn PA, Baars AE, Hijnen DJ, Schreurs CRG, van der Pol WL, Goedee HS, Vogelzang EH, Leeuw M, Atiqi S, van Vollenhoven R, Gerritsen M, van der Horst-Bruinsma IE, Lems WF, Nurmohamed MT, Boers M, Keijzer S, Keijser J, van de Sandt C, Boogaard A, Cristianawati O, Ten Brinke A, Verstegen NJM, Zwinderman KAH, van Ham SM, Rispens T, Kuijpers TW, Wolbink G, Eftimov F; T2B! immunity against SARS-CoV-2 study group.

Lancet Rheumatol. 2022 Jun;4(6):e417-e429. doi: 10.1016/S2665-9913(22)00102-3.

Case Report: A Highly Variable Clinical and Immunological Presentation of IKAROS Deficiency in a Single Family

Kuijpers TW, Tromp SAM, van Leeuwen EMM, de Bree GJ.

Front Immunol. 2022 Apr 11;13:865838. doi: 10.3389/fimmu.2022.865838.

Humoral responses after second and third SARS-CoV-2 vaccination in patients with immune-mediated inflammatory disorders on immunosuppressants: a cohort study.

Wieske L, van Dam KPJ, Steenhuis M, Stalman EW, Kummer LYL, van Kempen ZLE, Killestein J, Volkers AG, Tas SW, Boekel L, Wolbink GJ, van der Kooi AJ, Raaphorst J, Löwenberg M, Takkenberg RB, D'Haens GRAM, Spuls PI, Bekkenk MW, Musters AH, Post NF, Bosma AL, Hilhorst ML, Vegting Y, Bemelman FJ, Voskuyl AE, Broens B, Sanchez AP, van Els CACM, de Wit J, Rutgers A, de Leeuw K, Horváth B, Verschuuren JJGM, Ruiter AM, van Ouwerkerk L, van der Woude D, Allaart RCF, Teng YKO, van Paassen P, Busch MH, Jallah PBP, Brusse E, van Doorn PA, Baars AE, Hijnen DJ, Schreurs CRG, van der Pol WL, Goedee HS, Keijzer S, Keijser JBD, Boogaard A, Cristianawati O, Ten Brinke A, Verstegen NJM, Zwinderman KAH, van Ham SM, Kuijpers TW, Rispens T, Eftimov F; T2B! Immunity against SARS-CoV-2 study group.

Lancet Rheumatol. 2022 May;4(5):e338-e350. doi: 10.1016/S2665-9913(22)00034-0.

Risk factors associated with short-term adverse events after SARS-CoV-2 vaccination in patients with immune-mediated inflammatory diseases

Wieske L, Kummer LYL, van Dam KPJ, Stalman EW, van der Kooi AJ, Raaphorst J, Löwenberg M, Takkenberg RB, Volkers AG, D'Haens GRAM, Tas SW, Spuls PI, Bekkenk MW, Musters AH, Post NF, Bosma AL, Hilhorst ML, Vegting Y, Bemelman FJ, Killestein J, van Kempen ZLE, Voskuyl AE, Broens B, Sanchez AP, Wolbink G, Boekel L, Rutgers A, de Leeuw K, Horváth B, Verschuuren JJGM, Ruiter AM, van Ouwerkerk L, van der Woude D, Allaart CF, Teng YKO, van Paassen P, Busch MH, Jallah BP, Brusse E, van Doorn PA, Baars AE, Hijnen D, Schreurs CRG, van der Pol WL, Goedee HS, Steenhuis M, Rispens T, Ten Brinke A, Verstegen NJM, Zwinderman KAH, van Ham SM, Kuijpers TW, Eftimov F; T2B! immunity against SARS-CoV-2 study group.

BMC Med. 2022 Mar 2;20(1):100. doi: 10.1186/s12916-022-02310-7.

S100A8/A9 Is a Marker for the Release of Neutrophil Extracellular Traps and Induces Neutrophil Activation.

Sprenkeler EGG, Zandstra J, van Kleef ND, Goetschalckx I, Verstegen B, Aarts CEM, Janssen H, Tool ATJ, van Mierlo G, van Bruggen R, Jongerius I, Kuijpers TW.

Cells. 2022 Jan 11;11(2):236. doi: 10.3390/cells11020236.

Broad SARS-CoV-2 Neutralization by Monoclonal and Bispecific Antibodies Derived from a Gamma-infected Individual

Guerra D, Beaumont T, RadiÄ L, Kerster G, van der Straten K, Yuan M, Torres JL, Lee WH, Liu H, Poniman M, Bontjer I, Burger JA, Claireaux M, Caniels TG, Snitselaar JL, Bijl TPL, Kruijer S, Ozorowski G, Gideonse D, Sliepen K, Ward AB, Eggink D, de Bree GJ, Wilson IA, Sanders RW, van Gils MJ.

bioRxiv [Preprint]. 2022 Oct 14:2022.10.14.512216. doi: 10.1101/2022.10.14.512216.

Discriminating cross-reactivity in polyclonal IgG1 responses against SARS-CoV-2 variants of concern

van Rijswijck DMH, Bondt A, Hoek M, van der Straten K, Caniels TG, Poniman M, Eggink D, Reusken C, de Bree GJ, Sanders RW, van Gils MJ, Heck AJR.

Nat Commun. 2022 Oct 15;13(1):6103. doi: 10.1038/s41467-022-33899-1.

Recent infection with HCoV-OC43 may be associated with protection against SARS-CoV-2 infection

Lavell AHA, Sikkens JJ, Edridge AWD, van der Straten K, Sechan F, Oomen M, Buis DTP, Schinkel M, Burger JA, Poniman M, van Rijswijk J, de Jong MD, de Bree GJ, Peters EJG, Smulders YM, Sanders RW, van Gils MJ, van der Hoek L, Bomers MK.

iScience. 2022 Oct 21;25(10):105105. doi: 10.1016/j.isci.2022.105105.

A public antibody class recognizes an S2 epitope exposed on open conformations of SARS-CoV-2 spike

Claireaux M, Caniels TG, de Gast M, Han J, Guerra D, Kerster G, van Schaik BDC, Jongejan A, Schriek AI, Grobben M, Brouwer PJM, van der Straten K, Aldon Y, Capella-Pujol J, Snitselaar JL, Olijhoek W, Aartse A, Brinkkemper M, Bontjer I, Burger JA, Poniman M, Bijl TPL, Torres JL, Copps J, Martin IC, de Taeye SW, de Bree GJ, Ward AB, Sliepen K, van Kampen AHC, Moerland PD, Sanders RW, van Gils MJ. Nat Commun. 2022 Aug 4;13(1):4539. doi: 10.1038/s41467-022-32232-0.

Immunogenicity of the 13-valent pneumococcal conjugate vaccine followed by the 23-valent pneumococcal polysaccharide vaccine in people living with HIV on combination antiretroviral therapy

Garcia Garrido HM, Schnyder JL, Haydari B, Vollaard AM, Tanck MWT, de Bree GJ, Meek B, Grobusch MP, Goorhuis 

Int J Antimicrob Agents. 2022 Aug;60(2):106629. doi: 10.1016/j.ijantimicag.2022.106629.

The effect of SARS-CoV-2 vaccination on post-acute sequelae of COVID-19 (PASC): A prospective cohort study

Wynberg E, Han AX, Boyd A, van Willigen HDG, Verveen A, Lebbink R, van der Straten K, Kootstra N, van Gils MJ, Russell C, Leenstra T, de Jong MD, de Bree GJ, Prins M; RECoVERED Study Group. Vaccine. 2022 Jul 30;40(32):4424-4431. doi: 10.1016/j.vaccine.2022.05.090. Epub 2022 Jun 7.

Association between dexamethasone treatment and the host response in COVID-19 patients admitted to the general ward

de Brabander J, Michels EHA, van Linge CCA, Chouchane O, Douma RA, Reijnders TDY, Schuurman AR, van Engelen TSR; Amsterdam UMC COVID-19 biobank study group; Wiersinga WJ, van der Poll T. Respir Res. 2022 Jun 3;23(1):145. doi: 10.1186/s12931-022-02060-3.

Immunogenicity of the 13-Valent Pneumococcal Conjugate Vaccine (PCV13) Followed by the 23-Valent Pneumococcal Polysaccharide Vaccine (PPSV23) in Adults with and without Immunosuppressive Therapy

Garcia Garrido HM, Vollaard A, D'Haens GR, Spuls PI, Bemelman FJ, Tanck MW, de Bree GJ, Meek B, Grobusch MP, Goorhuis A.

Vaccines (Basel). 2022 May 17;10(5):795. doi: 10.3390/vaccines10050795.

Lung Microbiota of Critically Ill Patients with COVID-19 Are Associated with Nonresolving Acute Respiratory Distress Syndrome

Kullberg RFJ, de Brabander J, Boers LS, Biemond JJ, Nossent EJ, Heunks LMA, Vlaar APJ, Bonta PI, van der Poll T, Duitman J, Bos LDJ, Wiersinga WJ; ArtDECO Consortium and the Amsterdam UMC COVID-19 Biobank Study Group.

Am J Respir Crit Care Med. 2022 Oct 1;206(7):846-856. doi: 10.1164/rccm.202202-0274OC.

Antibody responses against SARS-CoV-2 variants induced by four different SARS-CoV-2 vaccines in health care workers in the Netherlands: A prospective cohort study

van Gils MJ, Lavell A, van der Straten K, Appelman B, Bontjer I, Poniman M, Burger JA, Oomen M, Bouhuijs JH, van Vught LA, Slim MA, Schinkel M, Wynberg E, van Willigen HDG, Grobben M, Tejjani K, van Rijswijk J, Snitselaar JL, Caniels TG; Amsterdam UMC COVID-19 S3/HCW study group; Vlaar APJ, Prins M, de Jong MD, de Bree GJ, Sikkens JJ, Bomers MK, Sanders RW.

 PLoS Med. 2022 May 17;19(5):e1003991. doi: 10.1371/journal.pmed.1003991.

Immunogenicity of the mRNA-1273 COVID-19 vaccine in adult patients with inborn errors of immunity

van Leeuwen LPM, GeurtsvanKessel CH, Ellerbroek PM, de Bree GJ, Potjewijd J, Rutgers A, Jolink H, van de Veerdonk F, van Gorp ECM, de Wilt F, Bogers S, Gommers L, Geers D, Bruns AHW, Leavis HL, van Haga JW, Lemkes BA, van der Veen A, de Kruijf-Bazen SFJ, van Paassen P, de Leeuw K, van de Ven AAJM, Verbeek-Menken PH, van Wengen A, Arend SM, Ruten-Budde AJ, van der Ent MW, van Hagen PM, Sanders RW, Grobben M, van der Straten K, Burger JA, Poniman M, Nierkens S, van Gils MJ, de Vries RD, Dalm VASHJ

Allergy Clin Immunol. 2022 Jun;149(6):1949-1957. doi: 10.1016/j.jaci.2022.04.002.

Neutralizing Antibody Therapies: Roadmap to Improve Clinical Effectiveness and Implementation

van der Straten K, van Gils MJ, de Taeye SW, de Bree GJ. Optimization of Anti-SARS-CoV-2

Front Med Technol. 2022 Mar 28;4:867982. doi: 10.3389/fmedt.2022.867982.

Immunogenicity of a 5-dose pneumococcal vaccination schedule following allogeneic hematopoietic stem cell transplantation

Garcia Garrido HM, Haggenburg S, Schoordijk MCE, Meijer E, Tanck MWT, Hazenberg MD, Rutten CE, de Bree GJ, Nur E, Meek B, Grobusch MP, Goorhuis A.

Am J Hematol. 2022 May;97(5):592-602. doi: 10.1002/ajh.26493. Epub 2022 Feb 17.

A single mRNA vaccine dose in COVID-19 patients boosts neutralizing antibodies against SARS-CoV-2 and variants of concern

van Gils MJ, van Willigen HDG, Wynberg E, Han AX, van der Straten K, Burger JA, Poniman M, Oomen M, Tejjani K, Bouhuijs JH, Verveen A, Lebbink R, Dijkstra M, Appelman B, Lavell AHA, Caniels TG, Bontjer I, van Vught LA, Vlaar APJ, Sikkens JJ, Bomers MK, Russell CA, Kootstra NA, Sanders RW, Prins M, de Bree GJ, de Jong MD; RECoVERED Study Group.

Cell Rep Med. 2021 Dec 14;3(1):100486. doi: 10.1016/j.xcrm.2021.100486.

Implementation of Early Next-Generation Sequencing for Inborn Errors of Immunity: A Prospective Observational Cohort Study of Diagnostic Yield and Clinical Implications in Dutch Genome Diagnostic Centers

Elsink K, Huibers MMH, Hollink IHIM, Simons A, Zonneveld-Huijssoon E, van der Veken LT, Leavis HL, Henriet SSV, van Deuren M, van de Veerdonk FL, Potjewijd J, Berghuis D, Dalm VASH, Vermont CL, van de Ven AAJM, Lambeck AJA, Abbott KM, van Hagen PM, de Bree GJ, Kuijpers TW, Frederix GWJ, van Gijn ME, van Montfrans JM; Genetics First for Primary Immunodeficiency Disorders Consortium. Front Immunol. 2021 Dec 21;12:780134. doi: 10.3389/fimmu.2021.780134.

Development of Resistance-Associated Mutations After Sotrovimab Administration in High-risk Individuals Infected With the SARS-CoV-2 Omicron Variant

Birnie E, Biemond JJ, Appelman B, de Bree GJ, Jonges M, Welkers MRA, Wiersinga WJ.

JAMA. 2022 Sep 20;328(11):1104-1107. doi: 10.1001/jama.2022.13854.

Treatment of an HLH-mimic disease based on HAVCR2 variants with absent TIM-3 expression

Tromp SAM, Gillissen MA, Bernelot Moens SJ, van Leeuwen EMM, Jansen MH, Koens L, Rutten CE, Kuijpers TW.

Blood Adv. 2022 Aug 9;6(15):4501-4505. doi: 10.1182/bloodadvances.2022007450.

Macrophages in Lupus Nephritis: Exploring a potential new therapeutic avenue

Kwant LE, Vegting Y, Tsang-A-Sjoe MWP, Kwakernaak AJ, Vogt L, Voskuyl AE, van Vollenhoven RF, de Winther MPJ, Bemelman FJ, Anders HJ, Hilhorst ML.

Autoimmun Rev. 2022 Dec;21(12):103211. doi: 10.1016/j.autrev.2022.103211.

Adult-onset autoinflammation caused by somatic mutations in UBA1: A Dutch case series of patients with VEXAS

van der Made CI, Potjewijd J, Hoogstins A, Willems HPJ, Kwakernaak AJ, de Sevaux RGL, van Daele PLA, Simons A, Heijstek M, Beck DB, Netea MG, van Paassen P, Elizabeth Hak A, van der Veken LT, van Gijn ME, Hoischen A, van de Veerdonk FL, Leavis HL, Rutgers A.

J Allergy Clin Immunol. 2022 Jan;149(1):432-439.e4. doi: 10.1016/j.jaci.2021.05.014.

Quantitative analysis of mRNA-1273 COVID-19 vaccination response in immunocompromised adult hematology patients

Haggenburg S, Lissenberg-Witte BI, van Binnendijk RS, den Hartog G, Bhoekhan MS, Haverkate NJE, de Rooij DM, van Meerloo J, Cloos J, Kootstra NA, Wouters D, Weijers SS, van Leeuwen EMM, Bontkes HJ, Tonouh-Aajoud S, Heemskerk MHM, Sanders RW, Roelandse-Koop E, Hofsink Q, Groen K, Çetinel L, Schellekens L, den Hartog YM, Toussaint B, Kant IMJ, Graas T, de Pater E, Dik WA, Engel MD, Pierie CRN, Janssen SR, van Dijkman E, Poniman M, Burger JA, Bouhuijs JH, Smits G, Rots NY, Zweegman S, Kater AP, van Meerten T, Mutsaers PGNJ, van Doesum JA, Broers AEC, van Gils MJ, Goorhuis A, Rutten CE, Hazenberg MD, Nijhof IS.

Blood Adv. 2022 Mar 8;6(5):1537-1546. doi: 10.1182/bloodadvances.2021006917.

SARS-CoV-2 vaccine-induced humoral and cellular immunity in patients with hematologic malignancies

Haggenburg S, Hofsink Q, Rutten CE, Nijhof IS, Hazenberg MD, Goorhuis A.

Semin Hematol. 2022 Oct;59(4):192-197. doi: 10.1053/j.seminhematol.2022.11.001. Epub 2022 Nov 19.

GATA2 haploinsufficient patients lack innate lymphoid cells that arise after hematopoietic cell transplantation

van Lier YF, Krabbendam L, Haverkate NJE, Zeerleder SS, Rutten CE, Blom B, Spits H, Hazenberg MD. Front Immunol. 2022 Oct 3;13:1020590. doi: 10.3389/fimmu.2022.1020590.

Genetic care in geographically isolated small island communities: 8 years of experience in the Dutch Caribbean

Verberne EA, Westermann JM, de Vries TI, Ecury-Goossen GM, Lo-A-Njoe SM, Manshande ME, Faries S, Veenhuis HD, Philippi P, Falix FA, Rosina-Angelista I, Ponson-Wever M, Rafael-Croes L, Thorsen P, Arends E, de Vroomen M, Nagelkerke SQ, Tilanus M, van der Veken LT, Huijsdens-van Amsterdam K, van der Kevie-Kersemaekers AM, Alders M, Mannens MMAM, van Haelst MM.

Am J Med Genet A. 2022 Jun;188(6):1777-1791. doi: 10.1002/ajmg.a.62708.

The BATTLE study: Effects of long-term tobramycin inhalation solution (TIS) once daily on exacerbation rate in patients with non-cystic fibrosis bronchiectasis. Study protocol of a double blind, randomized, placebo-controlled trial: study protocol

Terpstra LC, Altenburg J, Bronsveld I, Doodeman HJ, Rozemeijer W, Heijerman HGM, Boersma WG. Contemp Clin Trials Commun. 2022 Dec 6;30:101045. doi: 10.1016/j.conctc.2022.101045.

An S1-Nanoparticle Vaccine Protects against SARS-CoV-2 Challenge in K18-hACE2 Mice

van Oosten L, Yan K, Rawle DJ, Le TT, Altenburg JJ, Fougeroux C, Goksøyr L, Adriaan de Jongh W, Nielsen MA, Sander AF, Pijlman GP, Suhrbier A.

J Virol. 2022 Jul 27;96(14):e0084422. doi: 10.1128/jvi.00844-22.

Safety and Outcomes of Amikacin Liposome Inhalation Suspension for Mycobacterium abscessus Pulmonary Disease: A NTM-NET study

Henriette Zweijpfenning SM, Chiron R, Essink S, Schildkraut J, Akkerman OW, Aliberti S, Altenburg J, Arets B, van Braeckel E, Delaere B, Gohy S, Haarman E, Lorent N, McKew G, Morgan L, Wagner D, van Ingen J, Hoefsloot W.

Chest. 2022 Jul;162(1):76-81. doi: 10.1016/j.chest.2022.01.015.

The effect of maintenance azithromycin on radiological features in patients with bronchiectasis - Analysis from the BAT randomized controlled trial

Terpstra LC, Altenburg J, Mohamed Hoesein FA, Bronsveld I, Go S, van Rijn PAC, De Jong PA, Heijerman HGM, Boersma WG.

Respir Med. 2022 Feb;192:106718. doi: 10.1016/j.rmed.2021.106718.