Wetenschappelijk onderzoek

Naast de zorg voor patiënten verrichten we wetenschappelijk onderzoek op het gebied van diagnose en behandeling van primaire en verworven immuundeficiënties en immuundysregulatie.

In addition to patient care, we conduct scientific research into the diagnosis and treatment of primary and acquired immunodeficiencies and immunodysregulation.

Selectie publicaties 2025 / Selection publications 2025

A Pedigree With Complement Hyperactivation, Angiopathic Thrombosis, and Severe Protein-losing Enteropathy (CHAPLE) Disease: Variable Penetrance and Treatment With Pozelimab

De Boer ECW, Van Der Kruk N, Pouw RB, Van Limbergen JE, Kuijpers TW. 

Clin Gastroenterol Hepatol. 2025 Jun;23(7):1264-1267.e3. doi: 10.1016/j.cgh.2024.11.015. PMID: 39689772.

Multiomics dissection of human RAG deficiency reveals distinctive patterns of immune dysregulation but a common inflammatory signature

Bosticardo M, Dobbs K, Delmonte OM, Martins AJ, Pala F, Kawai T, Kenney H, Magro G, Rosen LB, Yamazaki Y, Yu HH, Calzoni E, Lee YN, Liu C, Stoddard J, Niemela J, Fink D, Castagnoli R, Ramba M, Cheng A, Riley D, Oikonomou V, Shaw E, Belaid B, Keles S, Al-Herz W, Cancrini C, Cifaldi C, Baris S, Sharapova S, Schuetz C, Gennery AR, Freeman AF, Somech R, Choo S, Giliani SC, Güngör T, Drozdov D, Meyts I, Moshous D, Neven B, Abraham RS, El-Marsafy A, Kanariou M, King A, Licciardi F, Cruz-Muñoz ME, Palma P, Poli C, Adeli M, Algeri M, Alroqi FJ, Bastard P, Bergerson JRE, Booth C, Brett A, Burns SO, Butte MJ, Padem N, de la Morena M, Dbaibo G, de Ravin SS, Dimitrova D, Djidjik R, Dorna MB, Dutmer CM, Elfeky R, Facchetti F, Fuleihan RL, Geha RS, Gonzalez-Granado LI, Haljasmägi L, Ale H, Hayward A, Hifanova AM, Ip W, Kaplan B, Kapoor N, Karakoc-Aydiner E, Kärner J, Keller MD, Dávila Saldaña BJ, Kiykim A, Kuijpers TW, Kuznetsova EE, Latysheva EA, Leiding JW, Locatelli F, Alva-Lozada G, McCusker C, Celmeli F, Morsheimer M, Ozen A, Parvaneh N, Pasic S, Plebani A, Preece K, Prockop S, Sakovich IS, Starkova EE, Torgerson T, Verbsky J, Walter JE, Ward B, Wisner EL, Draper D, Myint-Hpu K, Truong PM, Lionakis MS, Similuk MB; Centralized Sequencing Program Group§§; Walkiewicz MA, Klion A, Holland SM, Oguz C, Bogunovic D, Kisand K, Su HC, Tsang JS, Kuhns D, Villa A, Rosenzweig SD, Pittaluga S, Notarangelo LD; Centralized Sequencing Program Group. 

Sci Immunol. 2025 Jan 10;10(103):eadq1697. doi: 10.1126/sciimmunol.adq1697. Epub 2025 Jan 10. PMID: 39792639; PMCID: PMC12087669.

CD70 recruitment to the immunological synapse is dependent on CD20 in B cells

Arp AB, Abel Gutierrez A, Ter Beest M, Franken GA, Warner H, Rodgers Furones A, Kenyon AN, Jäger F, Cabrera-Orefice A, Kläsener K, van Deventer S, Droesen L, Dunlock VME, Classens R, Staniek J, Borst J, Reth M, Brandt U, Gros P, Kuijpers TW, Heemskerk MHM, Rizzi M, Querol Cano L, van Spriel AB. 

Proc Natl Acad Sci U S A. 2025 Apr 22;122(16):e2414002122. doi: 10.1073/pnas.2414002122. Epub 2025 Apr 15. PMID: 40232798; PMCID: PMC12037035.

Deep profiling of B cells responding to various pathogens uncovers compartments in IgG memory B cell and antibody-secreting lineages

Claireaux M, Elias G, Kerster G, Kuijper LH, Duurland MC, Paul AGA, Burger JA, Poniman M, Olijhoek W, de Jong N, de Jongh R, Wynberg E, van Willigen HDG, Prins M, De Bree GJ, de Jong MD, Kuijpers TW, Eftimov F, van der Schoot CE, Rispens T, Garcia-Vallejo JJ, Ten Brinke A, van Gils MJ, van Ham SM. 

Sci Adv. 2025 Feb 21;11(8):eado1331. doi: 10.1126/sciadv.ado1331. Epub 2025 Feb 19. PMID: 39970201; PMCID: PMC11837990.

Genetic determinants of the complement and coagulation pathways in invasive meningococcal disease

Bellos E, van Leeuwen K, Duret A, Hodeib S, Mashbat M, Kohlfuerst DS, Boeddha NP, Schlapbach LJ, Wright VJ, Fink CG, van der Flier M, van Deuren M, Sprong T, López-Trascasa M, López-Lera A, Martinón-Torres F, Salas A, Santillo D, Zenz W, Driessen GJ, Anderson ST, Secka F, Paulus S, de Groot R, Emonts M, Carrol ED, Herberg J, Levin M, Sancho-Shimizu V, Kuijpers TW; EUCLIDS Consortium. 

J Allergy Clin Immunol. 2025 Dec;156(6):1743-1751.e4. doi: 10.1016/j.jaci.2025.09.011. Epub 2025 Sep 21. PMID: 40987388.

IKBKB gain of function: An inborn error with clinical heterogeneity progressing toward combined immunodeficiency

Körholz J, Tromp SAM, Dalm VASH, de Bie M, de Bree GJ, van Leeuwen EMM, Fraaij PLA, Jansen MH, Hollink IHIM, Nagelkerke SQ, Russ S, Scholze AK, Soomann M, Wiedemuth R, Pachlopnik Schmid J, Hanitsch LG, Schuetz C, Kuijpers TW, IJspeert H. 

J Allergy Clin Immunol. 2025 Aug;156(2):279-293. doi: 10.1016/j.jaci.2025.04.033. Epub 2025 May 20. 

Tofacitinib treatment for psoriatic skin lesions associated with Aicardi-Goutières syndrome 7/Singleton-Merten syndrome 1

Beerepoot S, Grinwis L, Vanderver AL, van der Knaap MS, Kuijpers TW. 

Orphanet J Rare Dis. 2025 Apr 2;20(1):155. doi: 10.1186/s13023-025-03675-7. PMID: 40176112; PMCID: PMC11967008.

Novel pathogenic variants in CTLA4 and LRBA immune dysregulation: Reduced CTLA-4 expression with normal expression of co-stimulatory surface molecules

Tromp SAM, van Leeuwen EMM, Jansen MH, Kwakernaak AJ, Bomers MK, Jonkers RE, van Spaendonk RML, Kuijpers TW, de Bree GJ. 

Clin Immunol. 2025 Nov;280:110565. doi: 10.1016/j.clim.2025.110565. Epub 2025 Jul 10. PMID: 40651735.

Characterization of human CD34⁺ HSPC-derived neutrophils with limited myeloid-derived immunosuppressive cell activity

Webbers SDS, Gankema AAF, van Oosterom F, Rojas-Rodriguez F, Koops DS, Klaus AK, Geissler J, van Dam TJP, Matlung HL, van Bruggen R, Tercan H, Hoogendijk AJ, Kuijpers TW. 

iScience. 2025 Aug. 20;28(9):113404. doi: 10.1016/j.isci.2025.113404. PMID: 41054507; PMCID: PMC12496184.

Further Personalizing Medicine in Immune Disorders: Genomic Findings and Hematopoietic Cell Transplantation Survival

Similuk MN, Bannon SA, Yan J, Ghosh R, Damskey EE, Beers BJ, Orellana H, Byers S, Srinivasan S, Kamen MJ, Jodarski C, Moses RG, Reynolds-Lallement NC, Lewis KL, Seifert BA, Tokita MJ, Lack JB, Cao W, Sissung TM, Figg WD Sr, Dimitrova D, Kanakry JA, Hickstein DD, Shah NN, Gonzalez CE, Hughes TE, Zerbe CS, Su HC, Freeman AF, Uzel G, De Ravin SS, Kang EM, Malech HL, Rao VK, Lisco A, Fuss IJ, Cohen JI, Durkee-Shock JR, Delmonte OM, Bergerson JRE, Johnston JJ,

Biesecker LG, Kuijpers TW, Notarangelo LD, Holland SM, Walkiewicz MA. 

Transplantation. 2026 Jan 1;110(1):e166-e174. doi: 10.1097/TP.0000000000005504. Epub 2025 Jul 31. PMID: 40739694.

Evolution of SARS-CoV-2 antibody repertoire after successive mRNA vaccinations under immunosuppressive treatment

Keijser JBD, Stalman EW, Wieske L, Steenhuis M, van Dam KPJ, Kummer LYL, van Kempen ZLE, Killestein J, Volkers AG, Tas SW, Boekel L, Wolbink GJ, Blanco LF,

Verstegen NJM, Keijzer S, van Mierlo G, Cristianawati O, Boogaard AJ, van der Straten K, van Rijswijk J, van Gils MJ, Ten Brinke A, van Ham SM, Kuijpers TW,

Eftimov F, Rispens T; T2B! Immunity against SARS-CoV-2 study group. 

EBioMedicine. 2025 Mar;113:105620. doi: 10.1016/j.ebiom.2025.105620. Epub 2025 Feb 25. PMID: 40010153; PMCID: PMC11905820.

Mimickers of Systemic Lupus Erythematosus: Case Series and Literature Overview

Roest KL, Hak ALE, van Leeuwen EMM, de Bree GJ, Kwakernaak AJ.

J Clin Med. 2025 Oct 7;14(19):7070. doi: 10.3390/jcm14197070.

Enterovirus-associated deafness and myositis in an immunocompromised patient with in vivo and in vitro efficacy of intravenous immunoglobulins and remdesivir: Case report

de Koff EM, van Andel H, de Jong HK, van der Kooi AJ, Calitz C, Koen G, Kwakernaak AJ, Wolthers KC. 

Antivir Ther. 2025 Oct;30(5):13596535251385624. doi: 10.1177/13596535251385624. Epub 2025 Oct 8. PMID: 41061222. 

Self-reported Clinical Outcomes and Quality of Life in Agammaglobulinemia: the Importance of an Early Diagnosis

Blom M, Duintjer AJ, Jamee M, de Gier M, Bloomfield M, Klocperk A, Kralickova P, Karaca NE, Boyarchuk O, Čižnár P, Jeseňák M, Sharapova S, Skopovets E, Gonzalez-Granado LI, Palmeri S, Volpi S, Nalda AM, Tello SR, Soler-Palacín P, Abolhassani H, Pulvirenti F, Cinicola B, Wintergerst U, de Bree GJ, van den Berg JM, Leavis HL, Vermont C, Dalm VASH, van Aerde K, Henriet S, Jolink H, Potjewijd J, Lankester A, Mukherjee CR, Berghuis D, Pac M, Shillitoe BMJ, Gennery AR, van der Burg M. 

J Clin Immunol. 2025 Aug 25;45(1):125. doi: 10.1007/s10875-025-01904-z. Erratum in: J Clin Immunol. 2025 Oct 9;45(1):142. doi: 10.1007/s10875-025-01944-5. PMID: 40853601; PMCID: PMC12378137. 

Lymphocyte subsets and the increased risk for opportunistic infections in severe restrictive anorexia nervosa

Vidmar P, Altenburg J, van Leeuwen EM, van Bellegem ACM, Verhoef C, de Bree GJ, Soeters MR. 

J Eat Disord. 2025 May 19;13(1):84. doi: 10.1186/s40337-025-01235-9. PMID: 40390125; PMCID: PMC12090467. 

Selectie publicaties 2024 / Selection publications 2024

A phase 3 randomized trial of mavorixafor, a CXCR4 antagonist, for WHIM syndrome

Badolato R, Alsina L, Azar A, Bertrand Y, Bolyard AA, Dale D, Deyà-Martínez A, Dickerson KE, Ezra N, Hasle H, Kang HJ, Kiani-Alikhan S, Kuijpers TW, Kulagin A, Langguth D, Levin C, Neth O, Olbrich P, Peake J, Rodina Y, Rutten CE, Shcherbina A, Tarrant TK, Vossen MG, Wysocki CA, Belschner A, Bridger GJ, Chen K, Dubuc S, Hu Y, Jiang H, Li S, MacLeod R, Stewart M, Taveras AG, Yan T, Donadieu J. 

Blood. 2024 Jul 4;144(1):35-45. doi: 10.1182/blood.2023022658. PMID: 38643510; PMCID: PMC11251404.

Heterozygous BTNL8 variants in individuals with multisystem inflammatory syndrome in children (MIS-C)

Bellos E, Santillo D, Vantourout P, Jackson HR, Duret A, Hearn H, Seeleuthner Y, Talouarn E, Hodeib S, Patel H, Powell O, Yeoh S, Mustafa S, Habgood-Coote D, Nichols S, Estramiana Elorrieta L, D'Souza G, Wright VJ, Estrada-Rivadeneyra D, Tremoulet AH, Dummer KB, Netea SA, Condino-Neto A, Lau YL, Núñez Cuadros E, Toubiana J, Holanda Pena M, Rieux-Laucat F, Luyt CE, Haerynck F, Mège JL, Chakravorty S, Haddad E, Morin MP, Metin Akcan Ö, Keles S, Emiroglu M, Alkan G, Tüter Öz SK, Elmas Bozdemir S, Morelle G, Volokha A, Kendir-Demirkol Y, Sözeri B, Coskuner T, Yahsi A, Gulhan B, Kanik-Yuksek S, Bayhan GI, Ozkaya-Parlakay A, Yesilbas O, Hatipoglu N, Ozcelik T, Belot A, Chopin E, Barlogis V, Sevketoglu E, Menentoglu E, Gayretli Aydin ZG, Bloomfield M, AlKhater SA, Cyrus C,

Stepanovskiy Y, Bondarenko A, Öz FN, Polat M, Fremuth J, Lebl J, Geraldo A, Jouanguy E; COVID-19 Human Genetic Effort; DIAMONDS; EUCLIDS; Carter MJ, Wellman P, Peters M, Pérez de Diego R, Edwards LA, Chiu C, Noursadeghi M, Bolze A, Shimizu C, Kaforou M, Hamilton MS, Herberg JA, Schmitt EG, Rodriguez-Palmero A, Pujol A, Kim J, Cobat A, Abel L, Zhang SY, Casanova JL, Kuijpers TW, Burns JC, Levin M, Hayday AC, Sancho-Shimizu V. 

J Exp Med. 2024 Dec 2;221(12):e20240699. doi: 10.1084/jem.20240699. Epub 2024 Nov 22. PMID: 39576310; PMCID: PMC11586762.

Clinical and humoral response after SARS-CoV-2 breakthrough infection in patients receiving immunosuppressant therapy

Stalman EW, Wieske L, Keijser JBD, van Dam KPJ, Kummer LYL, Wilbrink MF, van Kempen ZLE, Killestein J, Volkers AG, Tas SW, Boekel L, Wolbink GJ, van der Kooi AJ, Raaphorst J, Löwenberg M, Takkenberg RB, D'Haens GRAM, Spuls PI, Bekkenk MW, Musters AH, Post NF, Bosma AL, Hilhorst ML, Vegting Y, Bemelman FJ, Voskuyl AE, Broens B, Parra Sanchez A, van Els CACM, de Wit J, Rutgers A, de Leeuw K, Horváth B, Verschuuren JJGM, Ruiter AM, van Ouwerkerk L, van der Woude D, Allaart RCF, Onno Teng YK, van Paassen P, Busch MH, Brusse E, van Doorn PA, Baars AE, Hijnen D, Schreurs CRG, van der Pol WL, Goedee HS, Steenhuis M, Keijzer S, Cristianawati O, Brinke AT, Verstegen NJM, Zwinderman KAH, van Ham SM, Rispens T, Welkers MR, Jonges M, Eftimov F, Kuijpers TW; T2B! immunity against SARS-CoV-2 study group. 

J Allergy Clin Immunol. 2024 Sep;154(3):754-766.e7. doi: 10.1016/j.jaci.2024.04.031. Epub 2024 May 17. PMID: 38763170.

Reduced myeloid commitment and increased uptake by macrophages of stem cell-derived HPS2 neutrophils

Webbers SD, Aarts CE, Klein B, Koops D, Geissler J, Tool AT, van Bruggen R, van den Akker E, Kuijpers TW. 

Life Sci Alliance. 2024 Jan 18;7(4):e202302263. doi: 10.26508/lsa.202302263. PMID: 38238087; PMCID: PMC10796564.

Targeting NF-κB signaling in B cells as a potential new treatment modality for ANCA-associated vasculitis

Merino-Vico A, van Hamburg JP, Tuijnenburg P, Frazzei G, Al-Soudi A, Bonasia CG, Helder B, Rutgers A, Abdulahad WH, Stegeman CA, Sanders JS, Bergamaschi L, Lyons PA, Bijma T, van Keep L, Wesenhagen K, Jongejan A, Olsson H, de Vries N, Kuijpers TW, Heeringa P, Tas SW. 

J Autoimmun. 2024 Jan;142:103133. doi: 10.1016/j.jaut.2023.103133. Epub 2023 Nov 8. PMID: 37931331.

Platelet proteomic profiling in sitosterolemia suggests thrombocytopenia is driven by lipid disorder and not platelet aberrations

Del Castillo J, Tool ATJ, van Leeuwen K, van Alphen FPJ, Brands MM, Suijker MH, Meijer AB, Hoogendijk AJ, Kuijpers TW. 

Blood Adv. 2024 May 28;8(10):2466-2477. doi: 10.1182/bloodadvances.2023012018. PMID: 38513134; PMCID: PMC11112606.

Kawasaki Disease Diagnosis and Treatment in over 1000 Patients: A Continuum of Dysregulated Inflammatory Responses

Netea SA, Biesbroek G, van Stijn D, Nagelkerke SQ, Kawasaki Study Group, CAHAL Group, KIRI Group, Kuipers IM, Kuijpers TW. 

Biomedicines. 2024 Sep 3;12(9):2014. doi: 10.3390/biomedicines12092014. PMID: 39335528; PMCID: PMC11428402.

Fc-mediated effector functions and memory B cell responses

van der Straten K, Guerra D, Kerster G, Claireaux M, Grobben M, Schriek AI, Boyd A, van Rijswijk J, Tejjani K, Eggink D, Beaumont T, de Taeye SW, de Bree GJ, Sanders RW, van Gils MJ. Primary SARS-CoV-2 variant of concern infections elicit broad antibody.

PLoS Pathog. 2024 Aug 15;20(8):e1012453. doi: 10.1371/journal.ppat.1012453. PMID: 39146376; PMCID: PMC11349224. 

 Inflammatory profiles are associated with long COVID up to 6 months after COVID-19 onset: A prospective cohort study of individuals with mild to critical COVID-19

Wynberg E, Han AX, van Willigen HDG, Verveen A, van Pul L, Maurer I, van Leeuwen EM, van den Aardweg JG, de Jong MD, Nieuwkerk P, Prins M, Kootstra NA, de Bree GJ; RECoVERED Study Group.

PLoS One. 2024 Jul 15;19(7):e0304990. doi: 10.1371/journal.pone.0304990. PMID: 39008486; PMCID: PMC11249251. 

A Robust Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-Specific T- and B-Cell Response Is Associated With Early Viral Clearance in SARS-CoV-2 Omicron-Infected Immunocompromised Individuals

Vergouwe M, Biemond JJ, van der Straten K, van Pul L, Kerster G, Claireaux M, Burger JA, van Dort KA, Kootstra NA, Jonges M, Welkers MRA, Hazenberg MD, Peters-Sengers H, van Gils MJ, Wiersinga WJ, Birnie E, de Bree GJ; TURN-COVID study group. 

J Infect Dis. 2024 Oct 16;230(4):e860-e871. doi: 10.1093/infdis/jiae306. PMID: 38843052; PMCID: PMC11481360. 

Immunogenicity of COVID-19 booster vaccination in IEI patients and their one year clinical follow-up after start of the COVID-19 vaccination program

van Leeuwen LPM, Grobben M, GeurtsvanKessel CH, Ellerbroek PM, de Bree GJ, Potjewijd J, Rutgers A, Jolink H, van de Veerdonk FL, van Gils MJ, de Vries RD, Dalm VASH; VACOPID Research Group. 

Front Immunol. 2024 Apr 18;15:1390022. doi: 10.3389/fimmu.2024.1390022. PMID: 38698851; PMCID: PMC11063285. 

Aberrant neutrophil degranulation in hospitalized patients with COVID-19 partially remains for 6 months

Hafkamp FMJ, Taanman-Kueter EWM, van Capel TMM, Wynberg E, van Willigen HDG, Verveen A, Kootstra NA, Nieuwkerk P, de Jong MD, de Bree GJ, Prins M; RECoVERED study group; Hazenberg MD, Groot Kormelink T, de Jong EC. 

Eur J Immunol. 2024 Jan;54(1):e2350404. doi: 10.1002/eji.202350404. Epub 2023 Oct 30. PMID: 37853954. 

Serum proteomics reveals hemophagocytic lymphohistiocytosis-like phenotype in a subset of patients with multisystem inflammatory syndrome in children

Tulling AJ, Holierhoek MG, Jansen-Hoogendijk AM, Hoste L, Haerynck F, Tavernier SJ, Oostenbrink R, Buysse CMP, Bannier MAGE, Bekhof J, Breukels M, Hammer SC, Jacobs MAM, Kamps AWA, van der Linden JW, Lebon A, Oudshoorn JH, Tramper-Stranders GA, Vastert SJ, Wieringa JW, Terheggen-Lagro SWJ, Wildenbeest JG, von Asmuth EGJ, van den Akker EB, van Gijn ME, Lugthart G, Buddingh EP. 

Clin Immunol. 2024 Jul;264:110252. doi: 10.1016/j.clim.2024.110252. Epub 2024 May 12. PMID: 38744408. 

The Human Phenotype Ontology in 2024: phenotypes around the world

Gargano MA, Matentzoglu N, Coleman B, Addo-Lartey EB, Anagnostopoulos AV, Anderton J, Avillach P, Bagley AM, Bakštein E, Balhoff JP, Baynam G, Bello SM, Berk M, Bertram H, Bishop S, Blau H, Bodenstein DF, Botas P, Boztug K, Čady J, Callahan TJ, Cameron R, Carbon SJ, Castellanos F, Caufield JH, Chan LE, Chute CG, Cruz-Rojo J, Dahan-Oliel N, Davids JR, de Dieuleveult M, de Souza V, de Vries BBA, de Vries E, DePaulo JR, Derfalvi B, Dhombres F, Diaz-Byrd C, Dingemans AJM, Donadille B, Duyzend M, Elfeky R, Essaid S, Fabrizzi C, Fico G, Firth HV, Freudenberg-Hua Y, Fullerton JM, Gabriel DL, Gilmour K, Giordano J, Goes FS, Moses RG, Green I, Griese M, Groza T, Gu W, Guthrie J, Gyori B, Hamosh A, Hanauer M, Hanušová K, He YO, Hegde H, Helbig I, Holasová K, Hoyt CT, Huang S, Hurwitz E, Jacobsen JOB, Jiang X, Joseph L, Keramatian K, King B, Knoflach K, Koolen DA, Kraus ML, Kroll C, Kusters M, Ladewig MS, Lagorce D, Lai MC, Lapunzina P, Laraway B, Lewis-Smith D, Li X, Lucano C, Majd M, Marazita ML, Martinez-Glez V, McHenry TH, McInnis MG, McMurry JA, Mihulová M, Millett CE, Mitchell PB, Moslerová V, Narutomi K, Nematollahi S, Nevado J, Nierenberg AA, Čajbiková NN, Nurnberger JI Jr, Ogishima S, Olson D, Ortiz A, Pachajoa H, Perez de Nanclares G, Peters A, Putman T, Rapp CK, Rath A, Reese J, Rekerle L, Roberts AM, Roy S, Sanders SJ, Schuetz C, Schulte EC, Schulze TG, Schwarz M, Scott K, Seelow D, Seitz B, Shen Y, Similuk MN, Simon ES, Singh B, Smedley D, Smith CL, Smolinsky JT, Sperry S, Stafford E, Stefancsik R, Steinhaus R, Strawbridge R, Sundaramurthi JC, Talapova P, Tenorio Castano JA, Tesner P, Thomas RH, Thurm A, Turnovec M, van Gijn ME, Vasilevsky NA, Vlčková M, Walden A, Wang K, Wapner R, Ware JS, Wiafe AA, Wiafe SA, Wiggins LD, Williams AE, Wu C, Wyrwoll MJ, Xiong H, Yalin N, Yamamoto Y, Yatham LN, Yocum AK, Young AH, Yüksel Z, Zandi PP, Zankl A, Zarante I, Zvolský M, Toro S, Carmody LC, Harris NL, Munoz-Torres MC, Danis D, Mungall CJ, Köhler S, Haendel MA, Robinson PN. 

Nucleic Acids Res. 2024 Jan 5;52(D1):D1333-D1346. doi: 10.1093/nar/gkad1005. PMID: 37953324; PMCID: PMC10767975. 

MOLGENIS VIP: an end-to-end DNA variant interpretation pipeline for research and diagnostics configurable to support rapid implementation of new methods

Maassen WTK, Johansson LF, Charbon B, Hendriksen D, van den Hoek S, Slofstra MK, Mulder R, Meems-Veldhuis MT, Sietsma R, Lemmink HH, van Diemen CC, van Gijn ME, Swertz MA, van der Velde KJ. 

NAR Genom Bioinform. 2025 Jun 23;7(2):lqaf087. doi: 10.1093/nargab/lqaf087. PMID: 40585303; PMCID: PMC12205968. 

Selectie publicaties 2023 / Selection publications 2023

Lack of eosinophil extracellular trap formation due to failure of plasma membrane breakdown in the absence of elastase

Sprenkeler EGG, Goetschalckx I, Fernández Hermira S, Tool ATJ, Hoogenboezem M, van Bruggen R, Kuijpers TW. 

Blood Adv. 2023 Jul 10:bloodadvances.2022009432. doi: 10.1182/bloodadvances.2022009432.

B-cell targeting with anti-CD38 daratumumab: implications for differentiation and memory responses

Verhoeven D, Grinwis L, Marsman C, Jansen MH; T2B Consortium; Van Leeuwen EM, Kuijpers TW. 

Life Sci Alliance. 2023 Jul 7;6(9):e202302214. doi: 10.26508/lsa.202302214.

Clinical Symptoms, Laboratory Parameters and Long-Term Follow-up in a National DADA2 Cohort

Andriessen MVE, Legger GE, Bredius RGM, van Gijn ME, Hak AE, Muller PCEH, Kamphuis S, Klouwer FCC, Kuijpers TW, Leavis HL, Nierkens S, Rutgers A, van der Veken LT, van Well GTJ, Mulders-Manders CM, van Montfrans JM. 

J Clin Immunol. 2023 Jun 5. doi: 10.1007/s10875-023-01521-8.

Efficient complement-mediated clearance of immunosuppressed T cells by macrophages

Gankema AAF, Furumaya C, Fernández-Hermira S, Hoogenboezem M, Matlung HL, van Bruggen R, Kuijpers TW. 

Front Immunol. 2023 May 16;14:1183180. doi: 10.3389/fimmu.2023.1183180.

Primary SARS-CoV-2 infection in patients with immune-mediated inflammatory diseases: long-term humoral immune responses and effects on disease activity

van Dam KPJ, Volkers AG, Wieske L, Stalman EW, Kummer LYL, van Kempen ZLE, Killestein J, Tas SW, Boekel L, Wolbink GJ, van der Kooi AJ, Raaphorst J, Takkenberg RB, D'Haens GRAM, Spuls PI, Bekkenk MW, Musters AH, Post NF, Bosma AL, Hilhorst ML, Vegting Y, Bemelman FJ, Voskuyl AE, Broens B, Sanchez AP, van Els CACM, de Wit J, Rutgers A, de Leeuw K, Horváth B, Verschuuren JJGM, Ruiter AM, van Ouwerkerk L, van der Woude D, Allaart RCF, Teng YKO, van Paassen P, Busch MH, Jallah PBP, Brusse E, van Doorn PA, Baars AE, Hijnen DJ, Schreurs CRG, van der Pol WL, Goedee HS, Steenhuis M, Keijzer S, Keijser JBD, Cristianawati O, Ten Brinke A, Verstegen NJM, van Ham SM, Rispens T, Kuijpers TW, Löwenberg M, Eftimov F; T2B! Immunity against SARS-CoV-2 study group.

BMC Infect Dis. 2023 May 17;23(1):332. doi: 10.1186/s12879-023-08298-6.

Humanized MISTRG as a preclinical in vivo model to study human neutrophil-mediated immune processes

Martinez-Sanz P, Laurent ARG, Slot E, Hoogenboezem M, Bąbała N, van Bruggen R, Rongvaux A, Flavell RA, Tytgat GAM, Franke K, Matlung HL, Kuijpers TW, Amsen D, Karrich JJ. 

Front Immunol. 2023 Mar 8;14:1105103. doi: 10.3389/fimmu.2023.1105103.

Distinct dynamics of antigen-specific induction and differentiation of different CD11c+Tbet+ B-cell subsets 

Steuten J, Bos AV, Kuijper LH, Claireaux M, Olijhoek W, Elias G, Duurland MC, Jorritsma T, Marsman C, Paul AGA, Garcia Vallejo JJ, van Gils MJ, Wieske L, Kuijpers TW, Eftimov F, van Ham SM, Ten Brinke A; T2B Consortium. 

J Allergy Clin Immunol. 2023 Feb 27:S0091-6749(23)00234-8. doi: 10.1016/j.jaci.2023.02.020.

Persistence of seroconversion at 6 months following primary immunisation in patients with immune-mediated inflammatory diseases

Wieske L, Stalman EW, van Dam PJK, Kummer LY, Steenhuis M, van Kempen ZLE, Killestein J, Volkers AG, Tas SW, Boekel L, Wolbink G, Van der Kooi A, Raaphorst J, Löwenberg M, Takkenberg B, D'Haens GRAM, Spuls PI, Bekkenk MW, Musters AH, Post NF, Bosma AL, Hilhorst ML, Vegting Y, Bemelman FJ, Voskuyl A, Broens B, Parra Sanchez A, van Els CACM, Wit J, Rutgers A, de Leeuw K, Horváth B, Verschuuren JJGM, Ruiter AM, van Ouwerkerk L, van der Woude D, Allaart CF, Teng YKO, van Paassen P, Busch MH, Jallah PBP, Brusse E, van Doorn PA, Baars AE, Hijnen D, Schreurs CRG, Van der Pol WL, Goedee HS, Keijzer S, Keijser J, Cristianawati O, Ten Brinke A, Verstegen NJM, Zwinderman KAH, van Ham SM, Kuijpers TW, Rispens T, Eftimov F; T2B! immunity against SARS-CoV-2 study group.

 Ann Rheum Dis. 2023 Jun;82(6):883-885. doi: 10.1136/ard-2022-223464.

Hematologically important mutations: Leukocyte adhesion deficiency (second update)

Roos D, van Leeuwen K, Madkaikar M, Kambli PM, Gupta M, Mathews V, Rawat A, Kuhns DB, Holland SM, de Boer M, Kanegane H, Parvaneh N, Lorenz M, Schwarz K, Klein C, Sherkat R, Jafari M, Wolach B, den Dunnen JT, Kuijpers TW, Köker MY. 

Blood Cells Mol Dis. 2023 Mar;99:102726. doi: 10.1016/j.bcmd.2023.102726.

Febrile illness in high-risk children: a prospective, international observational study

van der Velden FJS, de Vries G, Martin A, Lim E, von Both U, Kolberg L, Carrol ED, Khanijau A, Herberg JA, De T, Galassini R, Kuijpers TW, Martinón-Torres F, Rivero-Calle I, Vermont CL, Hagedoorn NN, Pokorn M, Pollard AJ, Schlapbach LJ, Tsolia M, Elefhteriou I, Yeung S, Zavadska D, Fink C, Voice M, Zenz W, Kohlmaier B, Agyeman PKA, Usuf E, Secka F, de Groot R, Levin M, van der Flier M, Emonts M; PERFORM consortium. 

Eur J Pediatr. 2023 Feb;182(2):555-556. doi: 10.1007/s00431-022-04788-y. Erratum for: Eur J Pediatr. 2023 Feb;182(2):543-554.

A Novel Deletion in FERMT3 Causes LAD-III in a Turkish Family

Köker N, Deveci İ, van Leeuwen K, Akbayram S, Roos D, Kuijpers TW, Köker MY. 

J Clin Immunol. 2023 May;43(4):741-746. doi: 10.1007/s10875-022-01420-4.

Neutrophil interactions with T cells, platelets, endothelial cells, and of course tumor cells

Segal BH, Giridharan T, Suzuki S, Khan ANH, Zsiros E, Emmons TR, Yaffe MB, Gankema AAF, Hoogeboom M, Goetschalckx I, Matlung HL, Kuijpers TW. 

Immunol Rev. 2023 Mar;314(1):13-35. doi: 10.1111/imr.13178

Health Outcomes and Cost-effectiveness of Monoclonal SARS-CoV-2 Antibodies as Pre-exposure Prophylaxis

Popping S, Nichols BE, Appelman B, Biemond JJ, Vergouwe M, Rosendaal FR, van der Valk M, de Bree GJ, Wiersinga WJ, Birnie E; TURN-COVID study group. 

JAMA Netw Open. 2023 Jul 3;6(7):e2321985. doi: 10.1001/jamanetworkopen.2023.21985.

Crosstalk between TLR8 and RIG-I-like receptors enhances antiviral immune responses

Vlaming KE, van Wijnbergen K, Kaptein TM, Nijhuis M, Kootstra NJ, de Bree GJ, Geijtenbeek TB. 

Front Med (Lausanne). 2023 May 16;10:1146457. doi: 10.3389/fmed.2023.1146457

Immune Responses 6 Months After mRNA-1273 COVID-19 Vaccination and the Effect of a Third Vaccination in Patients with Inborn Errors of Immunit

van Leeuwen LPM, Grobben M, GeurtsvanKessel CH, Ellerbroek PM, de Bree GJ, Potjewijd J, Rutgers A, Jolink H, van de Veerdonk FL, van Gils MJ, de Vries RD, Dalm VASH; VACOPID Research Group.

J Clin Immunol. 2023 Aug;43(6):1104-1117. doi: 10.1007/s10875-023-01514-7.

Fourth mRNA COVID-19 vaccination in immunocompromised patients with haematological malignancies (COBRA KAI): a cohort study

Hofsink Q, Haggenburg S, Lissenberg-Witte BI, Broers AEC, van Doesum JA, van Binnendijk RS, den Hartog G, Bhoekhan MS, Haverkate NJE, van Meerloo J, Burger JA, Bouhuijs JH, Smits GP, Wouters D, van Leeuwen EMM, Bontkes HJ, Kootstra NA, Vogels-Nooijen S, Rots N, van Beek J, Heemskerk MHM, Groen K, van Meerten T, Mutsaers PGNJ, van Gils MJ, Goorhuis A, Rutten CE, Hazenberg MD, Nijhof IS; COBRA KAI study team.

EClinicalMedicine. 2023 Jul;61:102040. doi: 10.1016/j.eclinm.2023.102040.

Clinical Symptoms, Laboratory Parameters and Long-Term Follow-up in a National DADA2 Cohort

Andriessen MVE, Legger GE, Bredius RGM, van Gijn ME, Hak AE, Muller PCEH, Kamphuis S, Klouwer FCC, Kuijpers TW, Leavis HL, Nierkens S, Rutgers A, van der Veken LT, van Well GTJ, Mulders-Manders CM, van Montfrans JM. 

J Clin Immunol. 2023 Oct;43(7):1581-1596. doi: 10.1007/s10875-023-01521-8. Epub 2023 Jun 5. PMID: 37277582; PMCID: PMC10499949. 

Rapid exome sequencing as a first-tier test in neonates with suspected genetic disorder: results of a prospective multicenter clinical utility study in the Netherlands

Olde Keizer RACM, Marouane A, Kerstjens-Frederikse WS, Deden AC, Lichtenbelt KD, Jonckers T, Vervoorn M, Vreeburg M, Henneman L, de Vries LS, Sinke RJ, Pfundt R, Stevens SJC, Andriessen P, van Lingen RA, Nelen M, Scheffer H, Stemkens D, Oosterwijk C, van Amstel HKP, de Boode WP, van Zelst-Stams WAG, Frederix GWJ, Vissers LELM; RADICON-NL consortium. 

Eur J Pediatr. 2023 Jun;182(6):2683-2692. doi: 10.1007/s00431-023-04909-1. Epub 2023 Mar 31. PMID: 36997769; PMCID: PMC10257607. 

Dysregulation of miRNA-30e-3p targeting IL-1β in an international cohort of systemic autoinflammatory disease patients

Akbaba TH, Akkaya-Ulum YZ, Batu ED, Penco F, Wittkowski H, Kant B, van Gijn ME, Foell D, Gattorno M, Ozen S, Balci-Peynircioglu B. 

J Mol Med (Berl). 2023 Jun;101(6):757-766. doi: 10.1007/s00109-023-02327-2. Epub 2023 May 22. PMID: 37212859. 

Selectie publicaties 2022 / Selection publications 2022

Breakthrough infections with the SARS-CoV-2 omicron (B.1.1.529) variant in patients with immune-mediated inflammatory diseases

Stalman EW, Wieske L, van Dam KPJ, Kummer LY, van Kempen ZLE, Killestein J, Volkers AG, Tas SW, Boekel L, Wolbink GJ, Van der Kooi AJ, Raaphorst J, Löwenberg M, Takkenberg RB, D'Haens GRAM, Spuls PI, Bekkenk MW, Musters AH, Post NF, Bosma AL, Hilhorst ML, Vegting Y, Bemelman FJ, Voskuyl AE, Broens B, Parra Sanchez A, van Els CACM, Wit J, Rutgers A, de Leeuw K, Horváth B, Verschuuren JJGM, Ruiter AM, van Ouwerkerk L, van der Woude D, Allaart CF, Teng OYK, van Paassen P, Busch MH, Jallah PBP, Brusse E, van Doorn PA, Baars AE, Hijnen DJ, Schreurs CRG, Van der Pol WL, Goedee HS, Steenhuis M, Keijzer S, Keijser JBD, Boogaard A, Cristianawati O, Ten Brinke A, Verstegen NJM, Zwinderman KAH, Rispens T, van Ham SM, Kuijpers TW, Eftimov F; T2B! immunity against SARS-CoV-2 study group.

Ann Rheum Dis. 2022 Dec;81(12):1757-1766. doi: 10.1136/ard-2022-222904.

SARS-CoV-2 breakthrough infections in patients with immune-mediated inflammatory diseases during the omicron dominant period

Boekel L, Besten YR, Hooijberg F, Wartena R, Steenhuis M, Vogelzang E, Leeuw M, Atiqi S, Tas SW, Lems WF, van Ham SM, Eftimov F, Stalman EW, Wieske L, Kuijpers TW, Voskuyl AE, van Vollenhoven RF, Gerritsen M, Krieckaert C, Rispens T, Boers M, Nurmohamed MT, Wolbink G.

Lancet Rheumatol. 2022 Nov;4(11):e747-e750. doi: 10.1016/S2665-9913(22)00221-1.

Megalobastic anemia, infantile leukemia, and immunodeficiency caused by a novel homozygous mutation in the DHFR gene

Kuijpers TW, de Vries ACH, van Leeuwen EM, Ermens ATAM, de Pont S, Smith DEC, Wamelink MMC, Mensenkamp AR, Nelen MR, Lango Allen H, Pals ST, Beverloo BHB, Huidekoper HH, Wagner A.

Blood Adv. 2022 Nov 22;6(22):5829-5834. doi: 10.1182/bloodadvances.2022007233.

Immunodeficiency, autoimmunity, and increased risk of B cell malignancy in humans with TRAF3 mutations

Rae W, Sowerby JM, Verhoeven D, Youssef M, Kotagiri P, Savinykh N, Coomber EL, Boneparth A, Chan A, Gong C, Jansen MH, du Long R, Santilli G, Simeoni I, Stephens J, Wu K, Zinicola M, Allen HL, Baxendale H, Kumararatne D, Gkrania-Klotsas E, Scheffler Mendoza SC, Yamazaki-Nakashimada MA, Ruiz LB, Rojas-Maruri CM, Lugo Reyes SO, Lyons PA, Williams AP, Hodson DJ, Bishop GA, Thrasher AJ, Thomas DC, Murphy MP, Vyse TJ, Milner JD, Kuijpers TW, Smith KGC

Sci Immunol. 2022 Aug 12;7(74):eabn3800. doi: 10.1126/sciimmunol.abn3800.

Heterozygous NOTCH1 Variants Cause CNS Immune Activation and Microangiopathy

Helman G, Zarekiani P, Tromp SAM, Andrews A, Botto LD, Bonkowsky JL, Chassevent A, Giorgio E, Pippucci T, Wei S, Smith-Hicks C, Vaula G, Willemsen MAAP, Schimmel M, Vollert K, Shimizu F, Kanda T, Lynch M, Roscioli T, Taft RJ, Simons C, Bugiani M, Kuijpers TW, van der Knaap MS.

Ann Neurol. 2022 Nov;92(5):895-901. doi: 10.1002/ana.26477.

Population genomics of Group B Streptococcus reveals the genetics of neonatal disease onset and meningeal invasion

Chaguza C, Jamrozy D, Bijlsma MW, Kuijpers TW, van de Beek D, van der Ende A, Bentley SD.

Nat Commun. 2022 Jul 21;13(1):4215. doi: 10.1038/s41467-022-31858-4.

Optimized Protocols for In-Vitro T-Cell-Dependent and T-Cell-Independent Activation for B-Cell Differentiation Studies Using Limited Cells

Marsman C, Verhoeven D, Koers J, Rispens T, Ten Brinke A, van Ham SM, Kuijpers TW.

Front Immunol. 2022 Jun 29;13:815449. doi: 10.3389/fimmu.2022.815449.

Cancer cells resist antibody-mediated destruction by neutrophils through activation of the exocyst complex

van Rees DJ, Bouti P, Klein B, Verkuijlen PJH, van Houdt M, Schornagel K, Tool ATJ, Venet D, Sotiriou C, El-Abed S, Izquierdo M, Guillaume S, Saura C, Di Cosimo S, Huober J, Roylance R, Kim SB, Kuijpers TW, van Bruggen R, K van den Berg T, Matlung HL.

J Immunother Cancer. 2022 Jun;10(6):e004820. doi: 10.1136/jitc-2022-004820.

Breakthrough SARS-CoV-2 infections with the delta (B.1.617.2) variant in vaccinated patients with immune-mediated inflammatory diseases using immunosuppressants: a substudy of two prospective cohort studies

Boekel L, Stalman EW, Wieske L, Hooijberg F, van Dam KPJ, Besten YR, Kummer LYL, Steenhuis M, van Kempen ZLE, Killestein J, Volkers AG, Tas SW, van der Kooi AJ, Raaphorst J, Löwenberg M, Takkenberg RB, D'Haens GRAM, Spuls PI, Bekkenk MW, Musters AH, Post NF, Bosma AL, Hilhorst ML, Vegting Y, Bemelman FJ, Voskuyl AE, Broens B, Parra Sanchez A, van Els CACM, de Wit J, Rutgers A, de Leeuw K, Horváth B, Verschuuren JJGM, Ruiter AM, van Ouwerkerk L, van der Woude D, Allaart CF, Teng YKO, van Paassen P, Busch MH, Jallah PBP, Brusse E, van Doorn PA, Baars AE, Hijnen DJ, Schreurs CRG, van der Pol WL, Goedee HS, Vogelzang EH, Leeuw M, Atiqi S, van Vollenhoven R, Gerritsen M, van der Horst-Bruinsma IE, Lems WF, Nurmohamed MT, Boers M, Keijzer S, Keijser J, van de Sandt C, Boogaard A, Cristianawati O, Ten Brinke A, Verstegen NJM, Zwinderman KAH, van Ham SM, Rispens T, Kuijpers TW, Wolbink G, Eftimov F; T2B! immunity against SARS-CoV-2 study group.

Lancet Rheumatol. 2022 Jun;4(6):e417-e429. doi: 10.1016/S2665-9913(22)00102-3.

Case Report: A Highly Variable Clinical and Immunological Presentation of IKAROS Deficiency in a Single Family

Kuijpers TW, Tromp SAM, van Leeuwen EMM, de Bree GJ.

Front Immunol. 2022 Apr 11;13:865838. doi: 10.3389/fimmu.2022.865838.

Humoral responses after second and third SARS-CoV-2 vaccination in patients with immune-mediated inflammatory disorders on immunosuppressants: a cohort study.

Wieske L, van Dam KPJ, Steenhuis M, Stalman EW, Kummer LYL, van Kempen ZLE, Killestein J, Volkers AG, Tas SW, Boekel L, Wolbink GJ, van der Kooi AJ, Raaphorst J, Löwenberg M, Takkenberg RB, D'Haens GRAM, Spuls PI, Bekkenk MW, Musters AH, Post NF, Bosma AL, Hilhorst ML, Vegting Y, Bemelman FJ, Voskuyl AE, Broens B, Sanchez AP, van Els CACM, de Wit J, Rutgers A, de Leeuw K, Horváth B, Verschuuren JJGM, Ruiter AM, van Ouwerkerk L, van der Woude D, Allaart RCF, Teng YKO, van Paassen P, Busch MH, Jallah PBP, Brusse E, van Doorn PA, Baars AE, Hijnen DJ, Schreurs CRG, van der Pol WL, Goedee HS, Keijzer S, Keijser JBD, Boogaard A, Cristianawati O, Ten Brinke A, Verstegen NJM, Zwinderman KAH, van Ham SM, Kuijpers TW, Rispens T, Eftimov F; T2B! Immunity against SARS-CoV-2 study group.

Lancet Rheumatol. 2022 May;4(5):e338-e350. doi: 10.1016/S2665-9913(22)00034-0.

Risk factors associated with short-term adverse events after SARS-CoV-2 vaccination in patients with immune-mediated inflammatory diseases

Wieske L, Kummer LYL, van Dam KPJ, Stalman EW, van der Kooi AJ, Raaphorst J, Löwenberg M, Takkenberg RB, Volkers AG, D'Haens GRAM, Tas SW, Spuls PI, Bekkenk MW, Musters AH, Post NF, Bosma AL, Hilhorst ML, Vegting Y, Bemelman FJ, Killestein J, van Kempen ZLE, Voskuyl AE, Broens B, Sanchez AP, Wolbink G, Boekel L, Rutgers A, de Leeuw K, Horváth B, Verschuuren JJGM, Ruiter AM, van Ouwerkerk L, van der Woude D, Allaart CF, Teng YKO, van Paassen P, Busch MH, Jallah BP, Brusse E, van Doorn PA, Baars AE, Hijnen D, Schreurs CRG, van der Pol WL, Goedee HS, Steenhuis M, Rispens T, Ten Brinke A, Verstegen NJM, Zwinderman KAH, van Ham SM, Kuijpers TW, Eftimov F; T2B! immunity against SARS-CoV-2 study group.

BMC Med. 2022 Mar 2;20(1):100. doi: 10.1186/s12916-022-02310-7.

S100A8/A9 Is a Marker for the Release of Neutrophil Extracellular Traps and Induces Neutrophil Activation.

Sprenkeler EGG, Zandstra J, van Kleef ND, Goetschalckx I, Verstegen B, Aarts CEM, Janssen H, Tool ATJ, van Mierlo G, van Bruggen R, Jongerius I, Kuijpers TW.

Cells. 2022 Jan 11;11(2):236. doi: 10.3390/cells11020236.

Broad SARS-CoV-2 Neutralization by Monoclonal and Bispecific Antibodies Derived from a Gamma-infected Individual

Guerra D, Beaumont T, RadiÄ L, Kerster G, van der Straten K, Yuan M, Torres JL, Lee WH, Liu H, Poniman M, Bontjer I, Burger JA, Claireaux M, Caniels TG, Snitselaar JL, Bijl TPL, Kruijer S, Ozorowski G, Gideonse D, Sliepen K, Ward AB, Eggink D, de Bree GJ, Wilson IA, Sanders RW, van Gils MJ.

bioRxiv [Preprint]. 2022 Oct 14:2022.10.14.512216. doi: 10.1101/2022.10.14.512216.

Discriminating cross-reactivity in polyclonal IgG1 responses against SARS-CoV-2 variants of concern

van Rijswijck DMH, Bondt A, Hoek M, van der Straten K, Caniels TG, Poniman M, Eggink D, Reusken C, de Bree GJ, Sanders RW, van Gils MJ, Heck AJR.

Nat Commun. 2022 Oct 15;13(1):6103. doi: 10.1038/s41467-022-33899-1.

Recent infection with HCoV-OC43 may be associated with protection against SARS-CoV-2 infection

Lavell AHA, Sikkens JJ, Edridge AWD, van der Straten K, Sechan F, Oomen M, Buis DTP, Schinkel M, Burger JA, Poniman M, van Rijswijk J, de Jong MD, de Bree GJ, Peters EJG, Smulders YM, Sanders RW, van Gils MJ, van der Hoek L, Bomers MK.

iScience. 2022 Oct 21;25(10):105105. doi: 10.1016/j.isci.2022.105105.

A public antibody class recognizes an S2 epitope exposed on open conformations of SARS-CoV-2 spike

Claireaux M, Caniels TG, de Gast M, Han J, Guerra D, Kerster G, van Schaik BDC, Jongejan A, Schriek AI, Grobben M, Brouwer PJM, van der Straten K, Aldon Y, Capella-Pujol J, Snitselaar JL, Olijhoek W, Aartse A, Brinkkemper M, Bontjer I, Burger JA, Poniman M, Bijl TPL, Torres JL, Copps J, Martin IC, de Taeye SW, de Bree GJ, Ward AB, Sliepen K, van Kampen AHC, Moerland PD, Sanders RW, van Gils MJ. Nat Commun. 2022 Aug 4;13(1):4539. doi: 10.1038/s41467-022-32232-0.

Immunogenicity of the 13-valent pneumococcal conjugate vaccine followed by the 23-valent pneumococcal polysaccharide vaccine in people living with HIV on combination antiretroviral therapy

Garcia Garrido HM, Schnyder JL, Haydari B, Vollaard AM, Tanck MWT, de Bree GJ, Meek B, Grobusch MP, Goorhuis 

Int J Antimicrob Agents. 2022 Aug;60(2):106629. doi: 10.1016/j.ijantimicag.2022.106629.

The effect of SARS-CoV-2 vaccination on post-acute sequelae of COVID-19 (PASC): A prospective cohort study

Wynberg E, Han AX, Boyd A, van Willigen HDG, Verveen A, Lebbink R, van der Straten K, Kootstra N, van Gils MJ, Russell C, Leenstra T, de Jong MD, de Bree GJ, Prins M; RECoVERED Study Group. Vaccine. 2022 Jul 30;40(32):4424-4431. doi: 10.1016/j.vaccine.2022.05.090. Epub 2022 Jun 7.

Association between dexamethasone treatment and the host response in COVID-19 patients admitted to the general ward

de Brabander J, Michels EHA, van Linge CCA, Chouchane O, Douma RA, Reijnders TDY, Schuurman AR, van Engelen TSR; Amsterdam UMC COVID-19 biobank study group; Wiersinga WJ, van der Poll T. Respir Res. 2022 Jun 3;23(1):145. doi: 10.1186/s12931-022-02060-3.

Immunogenicity of the 13-Valent Pneumococcal Conjugate Vaccine (PCV13) Followed by the 23-Valent Pneumococcal Polysaccharide Vaccine (PPSV23) in Adults with and without Immunosuppressive Therapy

Garcia Garrido HM, Vollaard A, D'Haens GR, Spuls PI, Bemelman FJ, Tanck MW, de Bree GJ, Meek B, Grobusch MP, Goorhuis A.

Vaccines (Basel). 2022 May 17;10(5):795. doi: 10.3390/vaccines10050795.

Lung Microbiota of Critically Ill Patients with COVID-19 Are Associated with Nonresolving Acute Respiratory Distress Syndrome

Kullberg RFJ, de Brabander J, Boers LS, Biemond JJ, Nossent EJ, Heunks LMA, Vlaar APJ, Bonta PI, van der Poll T, Duitman J, Bos LDJ, Wiersinga WJ; ArtDECO Consortium and the Amsterdam UMC COVID-19 Biobank Study Group.

Am J Respir Crit Care Med. 2022 Oct 1;206(7):846-856. doi: 10.1164/rccm.202202-0274OC.

Antibody responses against SARS-CoV-2 variants induced by four different SARS-CoV-2 vaccines in health care workers in the Netherlands: A prospective cohort study

van Gils MJ, Lavell A, van der Straten K, Appelman B, Bontjer I, Poniman M, Burger JA, Oomen M, Bouhuijs JH, van Vught LA, Slim MA, Schinkel M, Wynberg E, van Willigen HDG, Grobben M, Tejjani K, van Rijswijk J, Snitselaar JL, Caniels TG; Amsterdam UMC COVID-19 S3/HCW study group; Vlaar APJ, Prins M, de Jong MD, de Bree GJ, Sikkens JJ, Bomers MK, Sanders RW.

 PLoS Med. 2022 May 17;19(5):e1003991. doi: 10.1371/journal.pmed.1003991.

Immunogenicity of the mRNA-1273 COVID-19 vaccine in adult patients with inborn errors of immunity

van Leeuwen LPM, GeurtsvanKessel CH, Ellerbroek PM, de Bree GJ, Potjewijd J, Rutgers A, Jolink H, van de Veerdonk F, van Gorp ECM, de Wilt F, Bogers S, Gommers L, Geers D, Bruns AHW, Leavis HL, van Haga JW, Lemkes BA, van der Veen A, de Kruijf-Bazen SFJ, van Paassen P, de Leeuw K, van de Ven AAJM, Verbeek-Menken PH, van Wengen A, Arend SM, Ruten-Budde AJ, van der Ent MW, van Hagen PM, Sanders RW, Grobben M, van der Straten K, Burger JA, Poniman M, Nierkens S, van Gils MJ, de Vries RD, Dalm VASHJ

Allergy Clin Immunol. 2022 Jun;149(6):1949-1957. doi: 10.1016/j.jaci.2022.04.002.

Neutralizing Antibody Therapies: Roadmap to Improve Clinical Effectiveness and Implementation

van der Straten K, van Gils MJ, de Taeye SW, de Bree GJ. Optimization of Anti-SARS-CoV-2

Front Med Technol. 2022 Mar 28;4:867982. doi: 10.3389/fmedt.2022.867982.

Immunogenicity of a 5-dose pneumococcal vaccination schedule following allogeneic hematopoietic stem cell transplantation

Garcia Garrido HM, Haggenburg S, Schoordijk MCE, Meijer E, Tanck MWT, Hazenberg MD, Rutten CE, de Bree GJ, Nur E, Meek B, Grobusch MP, Goorhuis A.

Am J Hematol. 2022 May;97(5):592-602. doi: 10.1002/ajh.26493. Epub 2022 Feb 17.

A single mRNA vaccine dose in COVID-19 patients boosts neutralizing antibodies against SARS-CoV-2 and variants of concern

van Gils MJ, van Willigen HDG, Wynberg E, Han AX, van der Straten K, Burger JA, Poniman M, Oomen M, Tejjani K, Bouhuijs JH, Verveen A, Lebbink R, Dijkstra M, Appelman B, Lavell AHA, Caniels TG, Bontjer I, van Vught LA, Vlaar APJ, Sikkens JJ, Bomers MK, Russell CA, Kootstra NA, Sanders RW, Prins M, de Bree GJ, de Jong MD; RECoVERED Study Group.

Cell Rep Med. 2021 Dec 14;3(1):100486. doi: 10.1016/j.xcrm.2021.100486.

Implementation of Early Next-Generation Sequencing for Inborn Errors of Immunity: A Prospective Observational Cohort Study of Diagnostic Yield and Clinical Implications in Dutch Genome Diagnostic Centers

Elsink K, Huibers MMH, Hollink IHIM, Simons A, Zonneveld-Huijssoon E, van der Veken LT, Leavis HL, Henriet SSV, van Deuren M, van de Veerdonk FL, Potjewijd J, Berghuis D, Dalm VASH, Vermont CL, van de Ven AAJM, Lambeck AJA, Abbott KM, van Hagen PM, de Bree GJ, Kuijpers TW, Frederix GWJ, van Gijn ME, van Montfrans JM; Genetics First for Primary Immunodeficiency Disorders Consortium. Front Immunol. 2021 Dec 21;12:780134. doi: 10.3389/fimmu.2021.780134.

Development of Resistance-Associated Mutations After Sotrovimab Administration in High-risk Individuals Infected With the SARS-CoV-2 Omicron Variant

Birnie E, Biemond JJ, Appelman B, de Bree GJ, Jonges M, Welkers MRA, Wiersinga WJ.

JAMA. 2022 Sep 20;328(11):1104-1107. doi: 10.1001/jama.2022.13854.

Treatment of an HLH-mimic disease based on HAVCR2 variants with absent TIM-3 expression

Tromp SAM, Gillissen MA, Bernelot Moens SJ, van Leeuwen EMM, Jansen MH, Koens L, Rutten CE, Kuijpers TW.

Blood Adv. 2022 Aug 9;6(15):4501-4505. doi: 10.1182/bloodadvances.2022007450.

Macrophages in Lupus Nephritis: Exploring a potential new therapeutic avenue

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Blood Adv. 2022 Mar 8;6(5):1537-1546. doi: 10.1182/bloodadvances.2021006917.

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Semin Hematol. 2022 Oct;59(4):192-197. doi: 10.1053/j.seminhematol.2022.11.001. Epub 2022 Nov 19.

GATA2 haploinsufficient patients lack innate lymphoid cells that arise after hematopoietic cell transplantation

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Genetic care in geographically isolated small island communities: 8 years of experience in the Dutch Caribbean

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The BATTLE study: Effects of long-term tobramycin inhalation solution (TIS) once daily on exacerbation rate in patients with non-cystic fibrosis bronchiectasis. Study protocol of a double blind, randomized, placebo-controlled trial: study protocol

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An S1-Nanoparticle Vaccine Protects against SARS-CoV-2 Challenge in K18-hACE2 Mice

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J Virol. 2022 Jul 27;96(14):e0084422. doi: 10.1128/jvi.00844-22.

Safety and Outcomes of Amikacin Liposome Inhalation Suspension for Mycobacterium abscessus Pulmonary Disease: A NTM-NET study

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Chest. 2022 Jul;162(1):76-81. doi: 10.1016/j.chest.2022.01.015.

The effect of maintenance azithromycin on radiological features in patients with bronchiectasis - Analysis from the BAT randomized controlled trial

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